Overview

BioClin Therapeutics, Inc. is a privately-held biotechnology company developing a biologic to address medical conditions where there is a significant unmet need. Our lead program is a human monoclonal antibody, known as vofatamab, or B-701, that targets and blocks the activity of FGFR3 (fibroblast growth factor receptor 3) and is the most advanced FGFR3-specific antagonist in development. Vofatamab has been tested in two Phase 1 clinical trials involving 40 patients and demonstrated potential efficacy in patients with metastatic bladder cancer who were receiving it as 2nd line therapy. Currently, two proof-of-concept Phase 1b/2 studies with vofatamab in 2nd and 3rd line metastatic bladder cancer are being followed. There is significant unmet medical need in 3rd line advanced/metastatic bladder cancer, a disease in which patients have average progression free survival of two to three months, and survival of less than seven months.

Management Team

Scott Myers, Chairman and Chief Executive Officer

Scott Myers has more than 20 years of biopharmaceutical industry experience in product commercialization and corporate transactions. He was most recently CEO, President and a Director of Seattle-based Cascadian Therapeutics, a publicly-traded oncology company, until it was acquired by Seattle Genetics in March of 2018. Prior to Cascadian, he was CEO of Aerocrine AB, a medical device company based in Stockholm, Sweden, and Morrisville, NC, until it was acquired by Circassia, PLC in 2015. Prior to Aerocrine, Scott held senior commercial operations, general management and information management positions for UCB SA, a Belgium based biopharmaceutical company, and Johnson & Johnson. He is currently a Director of Harpoon Therapeutics, a private clinical-stage immuno-oncology company. Scott earned his BA in biology from Northwestern University and his MBA from The University of Chicago Booth School of Business.

Steve Abella, MD, Chief Medical Officer

Esteban (Steve) Abella has been actively involved in cancer clinical trials research for nearly 30 years including over 8 years in pharmaceutical industry, most recently at Gilead Sciences. At Gilead, Steve was a Senior Director leading the Non-Hodgkin’s lymphoma and leukemia efforts, as well as serving as a core member of the oncology senior leadership team. Prior to that he served as Executive Director at Amgen predominately responsible for the white cell franchise (Neulasta/Nepogen) global development efforts across clinical research and medical affairs. His clinical experiences over the 23 years prior joining industry, span 15 years in academic oncology, serving as a Professor of Pediatric, Oncology, and Medicine at the Barbara Ann Karmanos Cancer institute predominately focused in stem cell transplantation and oncology clinical trials. Subsequently, he focused on developing and serving as the initial group president for a large multispecialty private practice group in Arizona of over 60 physicians. Steve completed his fellowship and residency training at Wayne State University School of Medicine after graduating with a degree in medicine from the Universidad Central del Este. He attended the University of Pennsylvania for undergraduate studies.

Graeme Currie, Ph.D., Chief Operating Officer

Graeme Currie was most recently Vice President of Clinical Science and Operations at Dynavax Technologies Ltd. Graeme joined Dynavax in April 2016 and was a part of the team working towards approval of HEPLISAV-B and progressing the Immuno-oncology portfolio. Prior to that he spent six years at Regeneron Pharmaceuticals with the title Vice President of Clinical Project Management and Operations and oversaw all therapeutic areas, spanning 16 molecules and multiple therapeutic areas. Prior to Regeneron, Graeme was Vice President of Clinical Operations at Sepracor in Boston and at PDL Biopharma in the Bay Area. Graeme also spent 6 years as a Director at Gilead sciences working in Hepatitis and played a significant role in developing Hepsera for Chronic Hepatitis B. Prior to Gilead, he had roles at IPSEN and Glaxo Welcome, based in London and ran global programs for the development of Lanreotide for the treatment of Acromegaly and Valtrex for the treatment of HSV. Graeme received a BSc from the University of Salford in England and a PhD in Oncology from Aston University, Birmingham, England.

Julie Eastland, Chief Financial Officer and Chief Business Officer

Julie Eastland most recently served as Chief Financial Officer and Chief Business Officer of Cascadian Therapeutics, from September 2010 to May 2018, having helped negotiate the sale of the company to Seattle Genetics and then assisted in the subsequent transition. From 2006 to 2010, she was the Chief Financial Officer and Vice President of Finance and Operations of VLST Corporation, a privately-held biotechnology company. Prior to VLST, Julie held various financial and strategic management positions at publicly-traded biotechnology companies including Dendreon and Amgen. She is currently a Director of Pascal Biosciences, a publicly listed biotechnology company on the Toronto Venture Exchange. She received an MBA from Edinburgh University Management School and a BS in finance from Colorado State University.

Eric Emery, Vice President, Manufacturing

Eric Emery has 25 years of biologics manufacturing experience, most recently as Vice President, Manufacturing, and General Manager of the PDL BioPharma manufacturing site in Brooklyn Park, MN. From 1996 to 2008 he provided leadership for PDL in the maturation of a pilot scale clinical supply operation to a commercially ready one, including the construction and qualification of a 2 x 10kL and 2 x 1 kL multi-product antibody manufacturing facility. Prior to PDL, Eric worked for Baxter from 1983 to 1996 in their Los Angeles plasma fractionation facility, purifying coagulation factor proteins in production and technical services roles. Prior to joining BioClin, Eric provided Foundation and Biology department direction for North Hennepin Community College in Brooklyn Park, MN, where he also sponsored undergraduate science research. Eric received a B.S. in Biology from California State University, Los Angeles.

Valerie Fauvelle, Vice President, Regulatory Affairs

Valerie Fauvelle has more than 18 years of Regulatory Affairs experience in drug development. Prior to BioClin Therapeutics, Ms. Fauvelle worked at Cascadian Therapeutics, most recently as Senior Director, Regulatory Affairs, with primary responsibility for INDs and international submissions for treatments of multiple cancers. During her 8 years with Cascadian Therapeutics, she played a key role in the strategic development of the pivotal program for HER2+ breast cancer. Prior to Cascadian Therapeutics, she held positions with Gilead Sciences, ICOS, and Seattle Genetics, working on both biologics and small molecules targeting cancer, urology, respiratory and cardiovascular indications. She holds a BA in psychology from the University of Washington and a MSc in Health Sciences from The George Washington University School of Medicine. In addition, she has a Regulatory Affairs Certification (RAC) through the Regulatory Affairs Professional Society.

Stephen Lau, BioClin Founder and Advisor to Management Team

Board of Directors

Scott Myers, Chairman, President & Chief Executive Officer

Scott Myers has more than 20 years of biopharmaceutical industry experience in product commercialization and corporate transactions. He was most recently CEO, President and a Director of Seattle-based Cascadian Therapeutics, a publicly-traded oncology company, until it was acquired by Seattle Genetics in March of 2018. Prior to Cascadian, he was CEO of Aerocrine AB, a medical device company based in Stockholm, Sweden, and Morrisville, NC, until it was acquired by Circassia, PLC in 2015. Prior to Aerocrine, Scott held senior commercial operations, general management and information management positions for UCB SA, a Belgium based biopharmaceutical company, and Johnson & Johnson. He is currently a Director of Harpoon Therapeutics, a private clinical-stage immuno-oncology company. Scott earned his BA in biology from Northwestern University and his MBA from The University of Chicago Booth School of Business.

Fouad Azzam, Ph.D., MBA

Fouad Azzam, Ph.D., MBA, joined LSP in 2007. He became a General Partner of the firm in that same year. Fouad’s prime focus and responsibility within LSP is to invest in unlisted securities and manage the firm's North American operations. Prior to joining LSP, Fouad was the Managing Director of Eastman Ventures, the investment arm of Eastman Chemical Company, where he built-up its Healthcare and Advanced Materials practice. In his role as Managing Director, he was responsible for numerous early- and late-stage investments across the US & Europe. Fouad brings a wealth of investment expertise to the LSP team. Prior to his role at Eastman Ventures, Fouad held senior leadership positions at Eastman Chemical including roles in Innovation, Corporate Strategy, Corporate Development (M&A) and New Business Development. His career also includes business, operating, and technology roles at Occidental Chemical and BFGoodrich. Among others, Fouad is currently a Director at Illuminoss Medical, a company championing minimally invasive solutions for the stabilization and treatment of bone fractures. Fouad’s academic credentials include a Master’s degree and PhD in Chemical Engineering from the University of Akron in Ohio. In addition, Fouad obtained an MBA in Finance & Strategy from the University at Buffalo in New York. Fouad lives in the greater Boston area with his wife and two children.

David Kabakoff, Ph.D.

David joined Sofinnova as an Executive Partner in 2007. He represents Sofinnova as the Chairman of NextCure, and as Director of Antiva Biosciences, Dauntless Pharmaceuticals, and Principia. He also serves as Chairman of Lineagen and as a Director of bioTheranostics. Previously he served as the Chairman of both Trius Therapeutics and Amplimmune, and as a Director of InterMune and Allylix.

Prior to Sofinnova, David spent almost 30 years in industry leading technology and product development programs in the pharmaceutical, biopharmaceutical, and drug delivery fields. David co-founded Salmedix, a developer of cancer drug treatments, and served as the company’s Chairman and Chief Executive Officer. In June 2005, he negotiated the acquisition of Salmedix by Cephalon. David also held the positions of Executive Vice President of Dura and President and Chief Executive Officer of Spiros while at Dura Pharmaceuticals, a specialty respiratory pharmaceutical and pulmonary drug delivery company. Earlier, David was also employed as Chief Executive Officer of Corvas International and held senior executive positions with Hybritech.

David received his PhD from Yale University and his BA from Case Western Reserve University.

Joël Jean-Mairet, Ph.D.

Joël Jean-Mairet, Ph.D., is managing partner and co-founder of Ysios Capital. Previously, he co-founded Glycart Biotechnology AG in 2001 and was its CEO until the company was successfully sold to F. Hoffmann La-Roche four years later. Glycart Biotechnology was the originator of Gazyva ® approved for B-CLL by the FDA as first-ever breakthrough therapy. He holds an MS in Biotechnology and a Ph.D. from the Swiss Federal Institute of Technology (ETH) in Zurich.

Joël is currently on the boards of directors of AM-Pharma B.V., Aura Biosciences Inc, Sanifit S.L. and Chairman of Inbiomotion S.L. He has been Chairman of the board of Cellerix (now Tigenix NYSE Euronext TIG), on the boards of Medlumics S.L. and Dermaluics S.L. and board observer at Biovex, Inc. (now Amgen). Joël has earned numerous awards, including the Gold Medal of Wall Street Journal’s Europe Innovation Award in 2001.

David Lacey, M.D., Board Observer

Dr. David Lacey, formerly Senior Vice President of Discovery Research at Amgen, possesses over 20 years of scientific and senior leadership experience within the life sciences, focused on creating new medicines to make a difference in the lives of patients worldwide. During his tenure at Amgen, Dr. Lacey led an organization of more than 1200 scientists across a portfolio of drug discovery and development programs in the therapeutic areas of hematology/oncology, inflammation, metabolic disorders, and neuroscience. Dr. Lacey currently serves as a Board member for Nurix Inc., Atreca, and Inbiomotion SL, and acts as an advisor to a number of academic institutions, biotechnology companies, and is a Venture Partner at Ysios Capital.

Christian M. Richard, M.S, MBA

Christian Richard joined Tekla Capital Management in March of 2015 as Senior Vice President of Research. Previously, he was a Partner/Head of Research for Merlin Biomed Private Equity/Merlin Nexus for 12 years. Merlin Nexus is a cross-over life sciences fund focused on negotiated transactions in both late-stage private and public companies. Prior to Merlin Nexus, he spent almost five years in the Allergy/Immunology Group at the Schering-Plough Research Institute. He has a BS in Cellular and Molecular Biology from Purchase College and both an MS in Biochemistry and an MBA in Finance from NYU.

Mårten Steen, M.D., Ph.D.

Dr. Mårten Steen is a partner at HealthCap, and previously worked with global business development at Merck Serono, focusing on both product and technology licensing. Prior to Merck Serono, he was a medical associate with HealthCap. Mårten is a Medical Doctor trained at Lund University. He has pursued research in the field of protein chemistry and coagulation at Lund University and Novo Nordisk, rendering him a Ph.D. in Clinical Chemistry in 2003. He is the author of 16 scientific papers and published in peer-reviewed journals. He has also a B.Sc. degree in Business Administration from the Lund University School of Economics and Management. He serves on the board of Wilson Therapeutics AB, Immune Targeting Systems Ltd, and deputy member of the board of Nordic Nanovector AS. He previously served on the board of Ultragenyx Inc (RARE) and FerroKin Biosciences prior to its acquisition by Shire.

Joseph Turner

Joe Turner has been an active board member for a number of private and public biopharmaceutical companies. Joe previously served on the Board of Directors of several publicly-held biotechnology companies: Allos Therapeutics, Inc. (acquired by Spectrum Pharmaceuticals), QLT, Inc., and SGX Pharmaceuticals, Inc., (acquired by Lilly). Joe has also served on the Board of Directors of privately-held biotechnology companies: NovaCardia, Inc. (acquired by Merck & Co., Inc.), Sequel Pharmaceuticals, Inc., and ApopLogic Pharmaceuticals, Inc. Joe is currently a member of the Board of Directors of Alexza Pharmaceuticals, Inc., Corcept Therapeutics, Inc., Kythera Biopharmaceuticals, and Sophiris Bio. Joe also currently serves on the Board of Managers of Swarthmore College and the Board of Directors of the Linda Crnic Institute for Down Syndrome Research at the University of Colorado Medical School.

Previously, Joe was the Senior Vice President of Finance and Administration and Chief Financial Officer at Myogen, Inc. from 1999 until its acquisition by Gilead Sciences, Inc., in November 2006. Prior to Myogen, he served as Vice President, Finance and Chief Financial Officer at Centaur Pharmaceuticals, Inc. from 1997 to 1999 and as Vice President, Finance and Chief Financial Officer of Cortech, Inc. from 1992 to 1997. From 1979 to 1991, Joe worked at Eli Lilly and Company, where he held a variety of financial management positions both within the United States and abroad. Joe received his M.B.A. from the University of North Carolina at Chapel Hill, an M.A. in Molecular Biology from the University of Colorado at Boulder and a B.A. in Chemistry from Swarthmore College.


© BioClin Therapeutics, Inc.